Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Clin Pharmacol Ther
; 98(3): 266-87, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-26088472
ABSTRACT
The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Pharmaceutical Preparations
Type of study:
Guideline
/
Systematic_reviews
Limits:
Animals
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Clin Pharmacol Ther
Year:
2015
Document type:
Article
Affiliation country:
United States