The effect and distribution of a protein-bound polysaccharide preparation, PSK (Krestin), intratumorally injected prior to surgery into gastric cancer patients.
Acta Med Okayama
; 43(5): 289-97, 1989 Oct.
Article
in En
| MEDLINE
| ID: mdl-2610006
ABSTRACT
In order to improve the postoperative prognosis of gastric cancer patients we have performed preoperative endoscopic intratumoral administration of various biological response modifiers. In the present study we have investigated the kinetics and the immune response augmenting effect of intratumorally injected PSK, a protein-bound polysaccharide preparation, by immunohistochemical methods using anti-PSK antibody and various other antibodies. PSK-containing cells were located in the tumor tissues and follicular marginal zones of regional lymph nodes. Intratumorally administered PSK appeared to be phagocytized by the histiocytes and to cause them to become antigen-presenting cells. These cells may play a major role in augmenting immune responses in gastric cancer patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteoglycans
/
Stomach Neoplasms
/
Immunologic Factors
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Med Okayama
Year:
1989
Document type:
Article
Affiliation country:
Japan