The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.

Pajic, Marina; Herrmann, David; Vennin, Claire; Conway, James Rw; Chin, Venessa T; Johnsson, Anna-Karin E; Welch, Heidi Ce; Timpson, Paul

Pajic, Marina; Herrmann, David; Vennin, Claire; Conway, James Rw; Chin, Venessa T; Johnsson, Anna-Karin E; Welch, Heidi Ce; Timpson, Paul.

Affiliation

Pajic M; a The Kinghorn Cancer Center; Cancer Division; Garvan Institute of Medical Research ; Sydney , Australia.

Small GTPases ; 6(2): 123-33, 2015.

Article in En | MEDLINE | ID: mdl-26103062

Subject(s)

Neoplasms/metabolism; Second Messenger Systems; Tumor Microenvironment; rho GTP-Binding Proteins/metabolism; Animals; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Humans; Neoplasms/drug therapy; rho GTP-Binding Proteins/antagonists & inhibitors; rho GTP-Binding Proteins/genetics

Key words

ECM; FLIM; FRET; Rho GTPase; Rho inhibitors; cancer stroma; chemoresistance; collagen; intravital imaging

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Second Messenger Systems / Rho GTP-Binding Proteins / Tumor Microenvironment / Neoplasms Limits: Animals / Humans Language: En Journal: Small GTPases Year: 2015 Document type: Article Affiliation country: Australia

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