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Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
Fonseca, Emanuella M B; Trivella, Daniela B B; Scorsato, Valéria; Dias, Mariana P; Bazzo, Natália L; Mandapati, Kishore R; de Oliveira, Fábio L; Ferreira-Halder, Carmen V; Pilli, Ronaldo A; Miranda, Paulo C M L; Aparicio, Ricardo.
Affiliation
  • Fonseca EMB; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil.
  • Trivella DBB; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, CP 6154, CEP 13083-970, Campinas, SP, Brazil.
  • Scorsato V; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil.
  • Dias MP; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil.
  • Bazzo NL; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil.
  • Mandapati KR; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, CP 6154, CEP 13083-970, Campinas, SP, Brazil.
  • de Oliveira FL; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil.
  • Ferreira-Halder CV; Department of Biochemistry, Institute of Biology, University of Campinas, CEP 13083-862, Campinas, SP, Brazil.
  • Pilli RA; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, CP 6154, CEP 13083-970, Campinas, SP, Brazil.
  • Miranda PCML; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, CP 6154, CEP 13083-970, Campinas, SP, Brazil.
  • Aparicio R; Laboratory of Structural Biology and Crystallography, Institute of Chemistry, University of Campinas, CP 6154, 13083-970, Campinas, SP, Brazil. Electronic address: aparicio@iqm.unicamp.br.
Bioorg Med Chem ; 23(15): 4462-4471, 2015 Aug 01.
Article in En | MEDLINE | ID: mdl-26117648
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorous Acids / Proto-Oncogene Proteins / Protein Tyrosine Phosphatases Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorous Acids / Proto-Oncogene Proteins / Protein Tyrosine Phosphatases Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: Brazil