[Chromosomal aberrations--the cause of spontaneous abortions]. / Aberracje chromosomowe jako przyczyna poronien samoistnych.
Ginekol Pol
; 86(5): 357-61, 2015 May.
Article
in Pl
| MEDLINE
| ID: mdl-26117973
ABSTRACT
UNLABELLED The genetic factor remains the most frequent cause of spontaneous abortions. Examination of the fetal tissue from spontaneous miscarriages shows that 75% of them were caused by abnormal karyotype. Other reasons, albeit rare, included submicroscopic genomic rearrangements, monogenic diseases, and polygenic inheritance disorders of the embryo. OBJECTIVE:
The aim of the study was to analyze the incidence of chromosomal aberrations in material from the miscarriage. MATERIAL ANDMETHODS:
The study included 47 samples of miscarriage material from 47 women. Fluorescent hybridization in-situ (FISH) was used for genetic examination.RESULTS:
Chromosomal abnormalities were diagnosed in 72% of the samples, with trisomy 21 (25.5%), trisomy 16 (17%), and trisomy 18 (12.8%) as the most common. An abnormal number of copies of chromosome 18, 21, 22, indicating the coexistence of trisomy 18, 21, 22, was detected in 1 patient. It was another miscarriage in case of 14 subjects (29.8%).CONCLUSIONS:
Chromosomal aberrations were diagnosed in the majority of fetal tissue samples from spontaneous miscarriages. More than one chromosomal aberration in a single embryo is an extremely rare occurrence. Miscarriage due to chromosomal aberrations occurred in the vast majority of women > 35 years of age.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Abortion, Spontaneous
/
Chromosome Aberrations
/
Chromosomes, Human, 13-15
/
Chromosomes, Human, 16-18
/
Chromosomes, Human, 21-22 and Y
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Pl
Journal:
Ginekol Pol
Year:
2015
Document type:
Article