PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.

Kana, Kujaany; Song, Hannah; Laschinger, Carol; Zandstra, Peter W; Radisic, Milica

Kana, Kujaany; Song, Hannah; Laschinger, Carol; Zandstra, Peter W; Radisic, Milica.

Affiliation

Kana K; 1 Institute of Biomaterials and Biomedical Engineering , Toronto, Canada .
Song H; 1 Institute of Biomaterials and Biomedical Engineering , Toronto, Canada .
Laschinger C; 2 Department of Chemical Engineering and Applied Chemistry, University of Toronto , Canada .
Zandstra PW; 1 Institute of Biomaterials and Biomedical Engineering , Toronto, Canada .
Radisic M; 3 Heart & Stroke/Richard Lewar Centre of Excellence , Toronto, Canada .

Tissue Eng Part A ; 21(17-18): 2379-89, 2015 Sep.

Article in En | MEDLINE | ID: mdl-26120935

Subject(s)

Electrophysiological Phenomena; Heart/physiology; Phosphatidylinositol 3-Kinase/metabolism; Tissue Engineering/methods; Animals; Animals, Newborn; Chlorpropamide/analogs & derivatives; Chlorpropamide/pharmacology; Chromones/pharmacology; Disease Models, Animal; Electrophysiological Phenomena/drug effects; Gene Expression Profiling; Gene Expression Regulation/drug effects; Heart/drug effects; Insulin/pharmacology; Models, Biological; Morpholines/pharmacology; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tissue Engineering / Electrophysiological Phenomena / Phosphatidylinositol 3-Kinase / Heart Limits: Animals Language: En Journal: Tissue Eng Part A Journal subject: BIOTECNOLOGIA / HISTOLOGIA Year: 2015 Document type: Article Affiliation country: Canada Country of publication: United States

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