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Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic Plaques.
Rinne, Petteri; Hellberg, Sanna; Kiugel, Max; Virta, Jenni; Li, Xiang-Guo; Käkelä, Meeri; Helariutta, Kerttuli; Luoto, Pauliina; Liljenbäck, Heidi; Hakovirta, Harri; Gardberg, Maria; Airaksinen, Anu J; Knuuti, Juhani; Saraste, Antti; Roivainen, Anne.
Affiliation
  • Rinne P; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Hellberg S; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Kiugel M; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Virta J; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Li XG; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Käkelä M; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Helariutta K; Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland.
  • Luoto P; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Liljenbäck H; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Hakovirta H; Turku Center for Disease Modeling, University of Turku, Turku, Finland.
  • Gardberg M; Department of Surgery, University of Turku, Turku, Finland.
  • Airaksinen AJ; Department of Pathology, Turku University Hospital and University of Turku, Turku, Finland.
  • Knuuti J; Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland.
  • Saraste A; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
  • Roivainen A; Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
Mol Imaging Biol ; 18(1): 99-108, 2016 Feb.
Article in En | MEDLINE | ID: mdl-26122428
PURPOSE: Rupture-prone atherosclerotic plaques are characterized by accumulation of macrophages, which have shown to express somatostatin type 2 receptors. We aimed to investigate whether somatostatin receptor-targeting positron emission tomography (PET) tracers, [(68)Ga]DOTANOC, [(18)F]FDR-NOC, and [(68)Ga]DOTATATE, can detect inflamed atherosclerotic plaques. PROCEDURES: Atherosclerotic IGF-II/LDLR(-/-)ApoB(100/100) mice were studied in vivo and ex vivo for tracer uptake into atherosclerotic plaques. Furthermore, [(68)Ga]DOTANOC and [(68)Ga]DOTATATE were compared in a head-to-head setting for in vivo PET/X-ray computed tomography (CT) imaging characteristics. RESULTS: Ex vivo uptake of [(68)Ga]DOTANOC and [(68)Ga]DOTATATE in the aorta was higher in atherosclerotic mice compared to control C57Bl/6N mice, while the aortic uptake of [(18)F]FDR-NOC showed no genotype difference. Unlike [(18)F]FDR-NOC, [(68)Ga]DOTANOC and [(68)Ga]DOTATATE showed preferential binding to atherosclerotic plaques with plaque-to-wall ratio of 1.7 ± 0.3 and 2.1 ± 0.5, respectively. However, the aortic uptake and aorta-to-blood ratio of [(68)Ga]DOTANOC were higher compared to [(68)Ga]DOTATATE in in vivo PET/CT imaging. CONCLUSION: Our results demonstrate superior applicability for [(68)Ga]DOTANOC and [(68)Ga]DOTATATE in the detection of atherosclerotic plaques compared to [(18)F]FDR-NOC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Somatostatin / Radiopharmaceuticals / Positron-Emission Tomography / Plaque, Atherosclerotic Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Mol Imaging Biol Journal subject: BIOLOGIA MOLECULAR / DIAGNOSTICO POR IMAGEM Year: 2016 Document type: Article Affiliation country: Finland Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Somatostatin / Radiopharmaceuticals / Positron-Emission Tomography / Plaque, Atherosclerotic Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Mol Imaging Biol Journal subject: BIOLOGIA MOLECULAR / DIAGNOSTICO POR IMAGEM Year: 2016 Document type: Article Affiliation country: Finland Country of publication: United States