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P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib.
de Gooijer, Mark C; Zhang, Ping; Thota, Nishita; Mayayo-Peralta, Isabel; Buil, Levi C M; Beijnen, Jos H; van Tellingen, Olaf.
Affiliation
  • de Gooijer MC; Department of Bio-Pharmacology/ Mouse Cancer Clinic, The Netherlands Cancer Institute, AKL room C1.005, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • Zhang P; Department of Bio-Pharmacology/ Mouse Cancer Clinic, The Netherlands Cancer Institute, AKL room C1.005, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • Thota N; Department of Neurosurgery, Qilu Hospital, Shandong University, Wenhua Xi Road 107, 250012, Jinan, People's Republic China.
  • Mayayo-Peralta I; Department of Bio-Pharmacology/ Mouse Cancer Clinic, The Netherlands Cancer Institute, AKL room C1.005, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • Buil LC; Department of Bio-Pharmacology/ Mouse Cancer Clinic, The Netherlands Cancer Institute, AKL room C1.005, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • Beijnen JH; Department of Bio-Pharmacology/ Mouse Cancer Clinic, The Netherlands Cancer Institute, AKL room C1.005, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
  • van Tellingen O; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute /Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.
Invest New Drugs ; 33(5): 1012-9, 2015 Oct.
Article in En | MEDLINE | ID: mdl-26123925
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyridines / Brain Neoplasms / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Glioma Limits: Animals / Humans Language: En Journal: Invest New Drugs Year: 2015 Document type: Article Affiliation country: Netherlands Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyridines / Brain Neoplasms / ATP Binding Cassette Transporter, Subfamily B, Member 1 / ATP-Binding Cassette Transporters / Glioma Limits: Animals / Humans Language: En Journal: Invest New Drugs Year: 2015 Document type: Article Affiliation country: Netherlands Country of publication: United States