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Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
Horikoshi, Momoko; Mӓgi, Reedik; van de Bunt, Martijn; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Thorleifsson, Gudmar; Hӓgg, Sara; Hottenga, Jouke-Jan; Ladenvall, Claes; Ried, Janina S; Winkler, Thomas W; Willems, Sara M; Pervjakova, Natalia; Esko, Tõnu; Beekman, Marian; Nelson, Christopher P; Willenborg, Christina; Wiltshire, Steven; Ferreira, Teresa; Fernandez, Juan; Gaulton, Kyle J; Steinthorsdottir, Valgerdur; Hamsten, Anders; Magnusson, Patrik K E; Willemsen, Gonneke; Milaneschi, Yuri; Robertson, Neil R; Groves, Christopher J; Bennett, Amanda J; Lehtimӓki, Terho; Viikari, Jorma S; Rung, Johan; Lyssenko, Valeriya; Perola, Markus; Heid, Iris M; Herder, Christian; Grallert, Harald; Müller-Nurasyid, Martina; Roden, Michael; Hypponen, Elina; Isaacs, Aaron; van Leeuwen, Elisabeth M; Karssen, Lennart C; Mihailov, Evelin; Houwing-Duistermaat, Jeanine J; de Craen, Anton J M; Deelen, Joris; Havulinna, Aki S.
Affiliation
  • Horikoshi M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
  • Mӓgi R; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • van de Bunt M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
  • Surakka I; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland.
  • Sarin AP; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland.
  • Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
  • Thorleifsson G; deCode Genetic - Amgen Inc, Reykjavik, Iceland.
  • Hӓgg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Medical Sciences, Molecular Epidemiology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Hottenga JJ; Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
  • Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
  • Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Pervjakova N; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology and Center for Basic and Translational Obesity Research, Children's Hospital, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts,
  • Beekman M; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
  • Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research Leicester Cardiovascular Disease Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
  • Willenborg C; Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany; DZHK German Center for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany.
  • Wiltshire S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
  • Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Fernandez J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Steinthorsdottir V; deCode Genetic - Amgen Inc, Reykjavik, Iceland.
  • Hamsten A; Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Willemsen G; Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Milaneschi Y; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
  • Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
  • Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
  • Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
  • Lehtimӓki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
  • Viikari JS; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.
  • Rung J; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
  • Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Steno Diabetes Center A/S, Gentofte, Denmark.
  • Perola M; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland.
  • Heid IM; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
  • Herder C; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany.
  • Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany; Institute of Medical Informatics, Biometry and Epidemiology
  • Roden M; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany; Department of Endocrinology and Diabetology, University Hospi
  • Hypponen E; School of Population Health, University of South Australia, Adelaide, Australia; Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, United Kingdom.
  • Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
  • van Leeuwen EM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Karssen LC; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Houwing-Duistermaat JJ; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.
  • de Craen AJ; Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • Deelen J; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
  • Havulinna AS; Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland.
PLoS Genet ; 11(7): e1005230, 2015 Jul.
Article in En | MEDLINE | ID: mdl-26132169
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosome Mapping / Genetic Predisposition to Disease / Glycemic Index / Quantitative Trait Loci / Obesity Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosome Mapping / Genetic Predisposition to Disease / Glycemic Index / Quantitative Trait Loci / Obesity Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2015 Document type: Article Affiliation country: United kingdom Country of publication: United States