Increased noradrenergic neurotransmission to a pain facilitatory area of the brain is implicated in facilitation of chronic pain.

Martins, Isabel; Carvalho, Paulina; de Vries, Martin G; Teixeira-Pinto, Armando; Wilson, Steven P; Westerink, Ben H C; Tavares, Isaura

Martins, Isabel; Carvalho, Paulina; de Vries, Martin G; Teixeira-Pinto, Armando; Wilson, Steven P; Westerink, Ben H C; Tavares, Isaura.

Affiliation

Martins I; From the Departamento de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal (I.M., P.C., I.T.); Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal (I.M., P.C., I.T.); Department of Biomonitoring and Sensoring, University of Groningen, Groningen, The Netherlands (M.G.d.V., B.H.C.W.); Brains On-Line BV, Groningen, The Netherlands (M.G.d.V., B.H.C.W.); CINTESIS, Faculdade de Medicina, Universidade do Porto, Porto, Portugal (A.T

Anesthesiology ; 123(3): 642-53, 2015 Sep.

Article in En | MEDLINE | ID: mdl-26146901

Subject(s)

Adrenergic Neurons/metabolism; Chronic Pain/metabolism; Locus Coeruleus/metabolism; Medulla Oblongata/metabolism; Neuralgia/metabolism; Norepinephrine/metabolism; Adrenergic Neurons/pathology; Animals; Chronic Pain/pathology; Locus Coeruleus/pathology; Male; Medulla Oblongata/pathology; Neural Pathways/metabolism; Neural Pathways/pathology; Neuralgia/pathology; Pain Measurement/methods; Rats; Rats, Wistar; Synaptic Transmission/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Locus Coeruleus / Medulla Oblongata / Norepinephrine / Adrenergic Neurons / Chronic Pain / Neuralgia Limits: Animals Language: En Journal: Anesthesiology Year: 2015 Document type: Article Country of publication: United States

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