Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.

Huang, Nan-Lan; Lin, Jung-Hsin

Huang, Nan-Lan; Lin, Jung-Hsin.

Affiliation

Huang NL; Research Center for Applied Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan.
Lin JH; Research Center for Applied Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan School of Pharmacy, National Taiwan University, Taipei 10050, Taiwan jhlin@gate.sinica.edu.tw jlin@ntu.edu.tw.

Nucleic Acids Res ; 43(14): 6772-86, 2015 Aug 18.

Article in En | MEDLINE | ID: mdl-26150421

Subject(s)

DNA Cleavage; DNA Topoisomerases, Type II/chemistry; DNA/chemistry; DNA/metabolism; DNA Topoisomerases, Type II/metabolism; Etoposide/chemistry; Molecular Dynamics Simulation; Motion; Protein Structure, Tertiary; Topoisomerase II Inhibitors/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / DNA Topoisomerases, Type II / DNA Cleavage Type of study: Prognostic_studies Language: En Journal: Nucleic Acids Res Year: 2015 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom

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