Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner.

Lindemann, Carina; Marschall, Viola; Weigert, Andreas; Klingebiel, Thomas; Fulda, Simone

Lindemann, Carina; Marschall, Viola; Weigert, Andreas; Klingebiel, Thomas; Fulda, Simone.

Affiliation

Lindemann C; Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany.
Marschall V; Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany.
Weigert A; Institute of Biochemistry I, Goethe-University, Frankfurt, Germany.
Klingebiel T; Pediatric Hematology and Oncology, University Children's Hospital, Goethe-University, Frankfurt, Germany.
Fulda S; Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany; German Cancer Consortium (DKTK) Heidelberg, Germany; German Cancer Research Center (DKFZ) Heidelberg, Germany. Electronic address: simone.fulda@kgu.de.

Neoplasia ; 17(6): 481-9, 2015 Jun.

Article in En | MEDLINE | ID: mdl-26152356

Subject(s)

Cell Movement/drug effects; Chemokine CCL2/metabolism; Glioblastoma/pathology; Intracellular Signaling Peptides and Proteins/metabolism; Mitochondrial Proteins/metabolism; Oligopeptides/pharmacology; Tumor Microenvironment/drug effects; Apoptosis/drug effects; Apoptosis Regulatory Proteins; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Biomimetics; Blotting, Western; Brain Neoplasms/drug therapy; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Cell Proliferation/drug effects; Chemokine CCL2/genetics; Coculture Techniques; Gene Expression Profiling; Glioblastoma/drug therapy; Glioblastoma/metabolism; Humans; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondria/pathology; NF-kappa B/genetics; NF-kappa B/metabolism; Paracrine Communication; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Cell Movement / Glioblastoma / Chemokine CCL2 / Mitochondrial Proteins / Intracellular Signaling Peptides and Proteins / Tumor Microenvironment Type of study: Prognostic_studies Limits: Humans Language: En Journal: Neoplasia Journal subject: NEOPLASIAS Year: 2015 Document type: Article Affiliation country: Germany Country of publication: United States

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