Association between common carotid artery intima-media thickness and proteinuria in type 2 diabetic patients.
Iran J Kidney Dis
; 9(4): 311-5, 2015 Jul.
Article
in En
| MEDLINE
| ID: mdl-26174459
ABSTRACT
INTRODUCTION:
Proteinuria is the most reliable marker of diabetic nephropathy and an index of atherosclerosis and cardiovascular mortality in diabetic patients. In addition, common carotid artery intima-media thickness (CIMT) is a sensitive marker of early atherosclerosis and cardiovascular risk. The aim of this study was to evaluate the association between proteinuria and CIMT in type 2 diabetic patients. MATERIALS ANDMETHODS:
In a cross-sectional study, 154 patients with type 2 diabetes mellitus were enrolled. The CIMT was measured for all of the patients by one researcher. The 24-hour urine protein was measured using trichloroacetic acid method.RESULTS:
A total of 154 type 2 diabetic patients were enrolled with a mean diabetes mellitus duration of 8.91 ± 6.99 years (95 women and 55 men). The mean urinary protein in the patients was 294.70 ± 525.85 mg/24 h. The mean CIMT in all of the patients was 0.84 ± 0.19 mm, and it was greater in the men than in the women (P = .03). The CIMT significantly correlated with patients' age (P < .001), systolic blood pressure (P < .001), and urinary protein excretion (P = .001). There was a marginal positive correlation between diabetes mellitus duration and the CIMT (P = .049).CONCLUSIONS:
This study showed a significant association between CIMT, as a sensitive marker of macrovascular complication of diabetes mellitus, and proteinuria as an important index of microvascular complication of the disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteinuria
/
Carotid Artery, Common
/
Diabetes Mellitus, Type 2
/
Atherosclerosis
/
Carotid Intima-Media Thickness
Type of study:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Iran J Kidney Dis
Journal subject:
NEFROLOGIA
Year:
2015
Document type:
Article
Affiliation country:
Iran