Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists.
Eur J Med Chem
; 101: 681-91, 2015 Aug 28.
Article
in En
| MEDLINE
| ID: mdl-26210506
ABSTRACT
We report the synthesis and biological evaluation of new derivatives of Capadenoson, a former drug candidate that was previously advanced to phase IIa clinical trials. 19 of the 20 ligands show an affinity below 100 nM at the human adenosine A1 receptor (hA1AR) and display a wide range of residence times at this target (from approx. 5 min (compound 10) up to 132 min (compound 5)). Structure-affinity and structure-kinetics relationships were established, and computational studies of a homology model of the hA1AR revealed crucial interactions for both the affinity and dissociation kinetics of this family of ligands. These results were also combined with global metrics (Ligand Efficiency, cLogP), showing the importance of binding kinetics as an additional way to better select a drug candidate amongst seemingly similar leads.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiazoles
/
Receptor, Adenosine A1
/
Adenosine A1 Receptor Agonists
/
Aminopyridines
Limits:
Humans
Language:
En
Journal:
Eur J Med Chem
Year:
2015
Document type:
Article