A sensitive method for assay of a novel tricyclic compound using coulometric electrochemical detection.
J Pharm Sci
; 78(11): 971-4, 1989 Nov.
Article
in En
| MEDLINE
| ID: mdl-2621585
ABSTRACT
A reversed-phase high-performance liquid chromatographic method using coulometric electrochemical detection in the oxidative mode has been developed for the analysis of 3-(9-chloro-5,6-dihydro-11-H-pyrrolo[2,1-b][3]benzazepine-11-ylidene- N,N-dimethyl-1-propanamine(E)-Z-butenedioate hydrogen maleate (1) in plasma of patients dosed with 2-8 mg/kg/d of the drug. Concentrations as little as 0.1 ng/mL of 1 in plasma can be estimated with a mean coefficient of variation of 7.4 +/- 1.08%. The utility of the procedure was demonstrated by the analysis of 500 patient samples from a rising multiple-dose study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzazepines
/
Antidepressive Agents, Tricyclic
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
J Pharm Sci
Year:
1989
Document type:
Article