Occurrence of degradation products of chicken transferrin in murine circulating blood.
Jpn J Pharmacol
; 51(3): 397-401, 1989 Nov.
Article
in En
| MEDLINE
| ID: mdl-2622092
ABSTRACT
To determine the true survival of an exogenous substance in the circulation, it is requisite to assess that of the intact molecules. We studied the survival of chicken transferrin (Tf) in murine circulating blood after i.v. injection. With the aid of polyacrylamide-gel isoelectric focusing, direct immunofixation and densitometry, degradation products of chicken Tfs were found, and the disappearance rate of intact molecules was rather higher than that obtained by the single radial immunodiffusion method. These results strongly suggest that the degradation products must be taken into consideration in studies on the clearance of proteinous substances.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transferrin
Limits:
Animals
Language:
En
Journal:
Jpn J Pharmacol
Year:
1989
Document type:
Article
Affiliation country:
Japan