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Characterization of the acidic species of a monoclonal antibody using weak cation exchange chromatography and LC-MS.
Ponniah, Gomathinayagam; Kita, Adriana; Nowak, Christine; Neill, Alyssa; Kori, Yekaterina; Rajendran, Saravanamoorthy; Liu, Hongcheng.
Affiliation
  • Ponniah G; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
  • Kita A; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
  • Nowak C; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
  • Neill A; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
  • Kori Y; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
  • Rajendran S; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
  • Liu H; Product Characterization and ‡Biochemical Process Development, Alexion Pharmaceuticals Inc. , 352 Knotter Drive, Cheshire, Connecticut, 06410, United States.
Anal Chem ; 87(17): 9084-92, 2015 Sep 01.
Article in En | MEDLINE | ID: mdl-26222016
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Antibodies, Monoclonal Limits: Animals Language: En Journal: Anal Chem Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Antibodies, Monoclonal Limits: Animals Language: En Journal: Anal Chem Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States