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Evaluation of the dose enhancement of combined ¹°B + ¹57Gd neutron capture therapy (NCT).
Protti, N; Geninatti-Crich, S; Alberti, D; Lanzardo, S; Deagostino, A; Toppino, A; Aime, S; Ballarini, F; Bortolussi, S; Bruschi, P; Postuma, I; Altieri, S; Nikjoo, H.
Affiliation
  • Protti N; Department of Physics, University of Pavia, via Bassi 6, Pavia 27100, Italy National Institute of Nuclear Physics INFN, Section of Pavia, via Bassi 6, Pavia 27100, Italy nicoletta.protti@pv.infn.it.
  • Geninatti-Crich S; Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, Torino 10126, Italy.
  • Alberti D; Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, Torino 10126, Italy.
  • Lanzardo S; Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, Torino 10126, Italy.
  • Deagostino A; Department of Chemistry, University of Torino, via P.Giuria 7, Torino 10125, Italy.
  • Toppino A; Department of Chemistry, University of Torino, via P.Giuria 7, Torino 10125, Italy.
  • Aime S; Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, Torino 10126, Italy.
  • Ballarini F; Department of Physics, University of Pavia, via Bassi 6, Pavia 27100, Italy National Institute of Nuclear Physics INFN, Section of Pavia, via Bassi 6, Pavia 27100, Italy.
  • Bortolussi S; Department of Physics, University of Pavia, via Bassi 6, Pavia 27100, Italy National Institute of Nuclear Physics INFN, Section of Pavia, via Bassi 6, Pavia 27100, Italy.
  • Bruschi P; Department of Physics, University of Pavia, via Bassi 6, Pavia 27100, Italy.
  • Postuma I; Department of Physics, University of Pavia, via Bassi 6, Pavia 27100, Italy National Institute of Nuclear Physics INFN, Section of Pavia, via Bassi 6, Pavia 27100, Italy.
  • Altieri S; Department of Physics, University of Pavia, via Bassi 6, Pavia 27100, Italy National Institute of Nuclear Physics INFN, Section of Pavia, via Bassi 6, Pavia 27100, Italy.
  • Nikjoo H; Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE171 76, Sweden.
Radiat Prot Dosimetry ; 166(1-4): 369-73, 2015 Sep.
Article in En | MEDLINE | ID: mdl-26246584
ABSTRACT
An innovative molecule, GdBLDL, for boron neutron capture therapy (BNCT) has been developed and its effectiveness as a BNCT carrier is currently under evaluation using in vivo experiments on small animal tumour models. The molecule contains both (10)B (the most commonly used NCT agent) and (157)Gd nuclei. (157)Gd is the second most studied element to perform NCT, mainly thanks to its high cross section for the capture of low-energy neutrons. The main drawback of (157)Gd neutron capture reaction is the very short range and low-energy secondary charged particles (Auger electrons), which requires (157)Gd to be very close to the cellular DNA to have an appreciable biological effect. Treatment doses were calculated by Monte Carlo simulations to ensure the optimised tumour irradiation and the sparing of the healthy organs of the irradiated animals. The enhancement of the absorbed dose due to the simultaneous presence of (10)B and (157)Gd in the experimental set-up was calculated and the advantage introduced by the presence of (157)Gd was discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron / Radiotherapy Planning, Computer-Assisted / Mammary Neoplasms, Animal / Monte Carlo Method / Neutron Capture Therapy / Gadolinium Type of study: Evaluation_studies / Health_economic_evaluation Limits: Animals Language: En Journal: Radiat Prot Dosimetry Year: 2015 Document type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron / Radiotherapy Planning, Computer-Assisted / Mammary Neoplasms, Animal / Monte Carlo Method / Neutron Capture Therapy / Gadolinium Type of study: Evaluation_studies / Health_economic_evaluation Limits: Animals Language: En Journal: Radiat Prot Dosimetry Year: 2015 Document type: Article Affiliation country: Italy