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Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.
Wetmore, Barbara A; Wambaugh, John F; Allen, Brittany; Ferguson, Stephen S; Sochaski, Mark A; Setzer, R Woodrow; Houck, Keith A; Strope, Cory L; Cantwell, Katherine; Judson, Richard S; LeCluyse, Edward; Clewell, Harvey J; Thomas, Russell S; Andersen, Melvin E.
Affiliation
  • Wetmore BA; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137; bwetmore@thehamner.org.
  • Wambaugh JF; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711; and.
  • Allen B; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
  • Ferguson SS; Life Technologies, ADME/Tox Division of the Primary and Stem Cell Systems Business Unit, Durham, North Carolina 27703.
  • Sochaski MA; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
  • Setzer RW; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711; and.
  • Houck KA; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711; and.
  • Strope CL; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
  • Cantwell K; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
  • Judson RS; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711; and.
  • LeCluyse E; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
  • Clewell HJ; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
  • Thomas RS; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137; United States Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Caroli
  • Andersen ME; *The Hamner Institutes for Health Sciences, Institute for Chemical Safety Sciences, Research Triangle Park, North Carolina 27709-2137;
Toxicol Sci ; 148(1): 121-36, 2015 Nov.
Article in En | MEDLINE | ID: mdl-26251325
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxicity Tests / Enterocytes / Hepatocytes / High-Throughput Screening Assays / Toxicokinetics / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxicity Tests / Enterocytes / Hepatocytes / High-Throughput Screening Assays / Toxicokinetics / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Document type: Article