Systemic administration of strontium or NBD peptide ameliorates early stage cartilage degradation of mouse mandibular condyles.

Liu, Y-D; Yang, H-X; Liao, L-F; Jiao, K; Zhang, H-Y; Lu, L; Zhang, M; Zhang, J; He, J-J; Wu, Y-P; Chen, Di; Wang, M-Q

Liu, Y-D; Yang, H-X; Liao, L-F; Jiao, K; Zhang, H-Y; Lu, L; Zhang, M; Zhang, J; He, J-J; Wu, Y-P; Chen, Di; Wang, M-Q.

Affiliation

Liu YD; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Yang HX; Health Management Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.
Liao LF; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Jiao K; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Zhang HY; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Lu L; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Zhang M; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Zhang J; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
He JJ; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Wu YP; State Key Laboratory of Military Stomatology, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Chen D; Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, 145 Changlexi Road, Xi'an 710032, China.
Wang MQ; Department of Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.

Osteoarthritis Cartilage ; 24(1): 178-187, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26256766

Subject(s)

Cartilage, Articular/drug effects; Malocclusion; Mandibular Condyle/drug effects; Osteoclasts/drug effects; Peptides/pharmacology; RNA, Messenger/drug effects; Strontium/pharmacology; ADAM Proteins/drug effects; ADAM Proteins/genetics; ADAM Proteins/metabolism; ADAMTS5 Protein; Aggrecans/drug effects; Aggrecans/genetics; Aggrecans/metabolism; Animals; Cartilage, Articular/metabolism; Collagen Type II/drug effects; Collagen Type II/genetics; Collagen Type II/metabolism; Dental Occlusion; Female; I-kappa B Proteins/drug effects; I-kappa B Proteins/genetics; I-kappa B Proteins/metabolism; Immunohistochemistry; Interleukin-1beta/drug effects; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Mandibular Condyle/metabolism; Mandibular Condyle/pathology; Mice; Mice, Inbred C57BL; NF-KappaB Inhibitor alpha; Osteoclasts/metabolism; Osteoprotegerin/drug effects; Osteoprotegerin/genetics; Osteoprotegerin/metabolism; Proteoglycans/drug effects; Proteoglycans/metabolism; RANK Ligand/drug effects; RANK Ligand/genetics; RANK Ligand/metabolism; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Receptor Activator of Nuclear Factor-kappa B/drug effects; Receptor Activator of Nuclear Factor-kappa B/genetics; Receptor Activator of Nuclear Factor-kappa B/metabolism; Transcription Factor RelA/drug effects; Transcription Factor RelA/genetics; Transcription Factor RelA/metabolism; Tumor Necrosis Factor-alpha/drug effects; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism

Key words

Cartilage; Dental occlusion; NBD (NEMO-binding domain) peptide; Osteoarthritis; Strontium; Subchondral bone; Temporomandibular joint

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Peptides / Strontium / RNA, Messenger / Cartilage, Articular / Malocclusion / Mandibular Condyle Language: En Journal: Osteoarthritis Cartilage Journal subject: ORTOPEDIA / REUMATOLOGIA Year: 2016 Document type: Article Affiliation country: China Country of publication: United kingdom

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