Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60.
J Neurovirol
; 22(1): 80-7, 2016 Feb.
Article
in En
| MEDLINE
| ID: mdl-26265137
ABSTRACT
Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed resting state functional connectivity (rs-fc) data from HIV-infected and matched HIV-uninfected adults aged 60 years and older to determine associations between HIV status, neuropsychological performance, and clinical variables. HIV-infected participants with detectable plasma HIV RNA exhibited decreased rs-fc within the salience (SAL) network compared to HIV-infected participants with suppressed plasma HIV RNA. We did not identify differences in rs-fc within HIV-infected individuals by HAND status. Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus. However, these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
RNA, Viral
/
HIV Infections
/
Cognition Disorders
/
Anti-HIV Agents
/
Nerve Net
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neurovirol
Journal subject:
NEUROLOGIA
/
VIROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
United States