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Effects of penicillin and erythromycin on adherence of invasive and noninvasive isolates of Streptococcus pyogenes to laminin.
Smitran, Aleksandra; Vukovic, Dragana; Gajic, Ina; Marinkovic, Jelena; Ranin, Lazar.
Affiliation
  • Smitran A; Department of Microbiology and Immunology, Faculty of Medicine, University of Banja Luka, Banja Luka, Republic of Srpska, BA.
  • Vukovic D; Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, RS.
  • Gajic I; Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, RS.
  • Marinkovic J; Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, RS.
  • Ranin L; Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, RS.
Mem Inst Oswaldo Cruz ; 110(5): 684-6, 2015 Aug.
Article in En | MEDLINE | ID: mdl-26270594
This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the adherence displayed by isolates of low invasiveness. Antibiotic treatment caused significant reductions in adherence to laminin in all three groups of strains. Penicillin was more successful in reducing the adherence abilities of the tested GAS strains than erythromycin.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillins / Streptococcus pyogenes / Bacterial Adhesion / Erythromycin / Laminin / Anti-Bacterial Agents Limits: Humans Language: En Journal: Mem Inst Oswaldo Cruz Year: 2015 Document type: Article Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillins / Streptococcus pyogenes / Bacterial Adhesion / Erythromycin / Laminin / Anti-Bacterial Agents Limits: Humans Language: En Journal: Mem Inst Oswaldo Cruz Year: 2015 Document type: Article Country of publication: Brazil