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The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.
Ganapathi, Lakshmi; Van Haren, Simon; Dowling, David J; Bergelson, Ilana; Shukla, Nikunj M; Malladi, Subbalakshmi S; Balakrishna, Rajalakshmi; Tanji, Hiromi; Ohto, Umeharu; Shimizu, Toshiyuki; David, Sunil A; Levy, Ofer.
Affiliation
  • Ganapathi L; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
  • Van Haren S; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
  • Dowling DJ; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
  • Bergelson I; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States of America.
  • Shukla NM; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America.
  • Malladi SS; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America.
  • Balakrishna R; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America.
  • Tanji H; Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
  • Ohto U; Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
  • Shimizu T; Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
  • David SA; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America.
  • Levy O; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
PLoS One ; 10(8): e0134640, 2015.
Article in En | MEDLINE | ID: mdl-26274907
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Recombinant Fusion Proteins / Cytokines / Toll-Like Receptor 7 / Toll-Like Receptor 8 / Imidazoles / Leukocytes Limits: Adult / Female / Humans / Newborn / Pregnancy Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Recombinant Fusion Proteins / Cytokines / Toll-Like Receptor 7 / Toll-Like Receptor 8 / Imidazoles / Leukocytes Limits: Adult / Female / Humans / Newborn / Pregnancy Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States