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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.
Font-Burgada, Joan; Shalapour, Shabnam; Ramaswamy, Suvasini; Hsueh, Brian; Rossell, David; Umemura, Atsushi; Taniguchi, Koji; Nakagawa, Hayato; Valasek, Mark A; Ye, Li; Kopp, Janel L; Sander, Maike; Carter, Hannah; Deisseroth, Karl; Verma, Inder M; Karin, Michael.
Affiliation
  • Font-Burgada J; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: jfontburgada@ucsd.edu.
  • Shalapour S; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Ramaswamy S; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Hsueh B; Departments of Bioengineering, Psychiatry, and Behavioral Sciences, Neurosciences Program, Howard Hughes Medical Institute, Stanford University, 318 Campus Drive West, Clark Center W080, Stanford, CA 94305, USA.
  • Rossell D; Department of Statistics, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
  • Umemura A; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Taniguchi K; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Nakagawa H; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Gastroenterology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655.
  • Valasek MA; Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Ye L; Departments of Bioengineering, Psychiatry, and Behavioral Sciences, Neurosciences Program, Howard Hughes Medical Institute, Stanford University, 318 Campus Drive West, Clark Center W080, Stanford, CA 94305, USA.
  • Kopp JL; Department of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Cellular & Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver,
  • Sander M; Department of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Carter H; Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Deisseroth K; Departments of Bioengineering, Psychiatry, and Behavioral Sciences, Neurosciences Program, Howard Hughes Medical Institute, Stanford University, 318 Campus Drive West, Clark Center W080, Stanford, CA 94305, USA.
  • Verma IM; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Karin M; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 9209
Cell ; 162(4): 766-79, 2015 Aug 13.
Article in En | MEDLINE | ID: mdl-26276631
ABSTRACT
Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration and maintenance but also promotes development of hepatocellular carcinoma (HCC). Despite extensive investigation, the cells responsible for hepatocyte restoration or HCC development remain poorly characterized. We used genetic lineage tracing to identify cells responsible for hepatocyte replenishment following chronic liver injury and queried their roles in three distinct HCC models. We found that a pre-existing population of periportal hepatocytes, located in the portal triads of healthy livers and expressing low amounts of Sox9 and other bile-duct-enriched genes, undergo extensive proliferation and replenish liver mass after chronic hepatocyte-depleting injuries. Despite their high regenerative potential, these so-called hybrid hepatocytes do not give rise to HCC in chronically injured livers and thus represent a unique way to restore tissue function and avoid tumorigenesis. This specialized set of pre-existing differentiated cells may be highly suitable for cell-based therapy of chronic hepatocyte-depleting disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2015 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2015 Document type: Article