Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics.
Turk J Med Sci
; 45(3): 619-26, 2015.
Article
in En
| MEDLINE
| ID: mdl-26281329
ABSTRACT
BACKGROUND/AIM:
To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. MATERIALS ANDMETHODS:
The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT).RESULTS:
At the baseline, patients in the HS group had a higher percentage of bleeding on probing than those in the C and HD groups. Hyperlipidaemics had higher serum triglyceride levels than the control group at 2MPT compared to the baseline. At 2MPT, the levels of Lp-PLA2 in the HS group were significantly higher compared to the baseline and 1WPT. There were no statistically significant differences in CRP levels between study periods for all groups.CONCLUSION:
The periodontal treatment may affect the inflammatory control of hyperlipidaemic patients with periodontitis via increased Lp-PLA2 levels and severity of the impaired lipid metabolism. These findings may be important regarding the therapeutic strategies for hyperlipidaemics with periodontitis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Periodontitis
/
1-Alkyl-2-acetylglycerophosphocholine Esterase
/
Hyperlipidemias
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Turk J Med Sci
Year:
2015
Document type:
Article
Country of publication:
TR
/
TURKEY
/
TURQUIA