miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation.

Bhatwadekar, Ashay D; Yan, Yuanqing; Stepps, Valerie; Hazra, Sugata; Korah, Maria; Bartelmez, Stephen; Chaqour, Brahim; Grant, Maria B

Bhatwadekar, Ashay D; Yan, Yuanqing; Stepps, Valerie; Hazra, Sugata; Korah, Maria; Bartelmez, Stephen; Chaqour, Brahim; Grant, Maria B.

Affiliation

Bhatwadekar AD; Department of Ophthalmology, Indiana University, Indianapolis, IN.
Yan Y; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL.
Stepps V; BetaStem Therapeutics, Sausalito, CA.
Hazra S; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL.
Korah M; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL.
Bartelmez S; BetaStem Therapeutics, Sausalito, CA.
Chaqour B; Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY.
Grant MB; Department of Ophthalmology, Indiana University, Indianapolis, IN mabgrant@iupui.edu.

Diabetes ; 64(12): 4226-37, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26283734

Subject(s)

Cell Differentiation; Diabetic Retinopathy/pathology; Endothelial Progenitor Cells/pathology; Endothelium, Vascular/pathology; MicroRNAs/metabolism; Period Circadian Proteins/metabolism; AC133 Antigen; Antigens, CD/metabolism; Antigens, CD34/blood; Antigens, CD34/metabolism; Biomarkers/blood; Biomarkers/metabolism; CLOCK Proteins/antagonists & inhibitors; CLOCK Proteins/blood; CLOCK Proteins/genetics; CLOCK Proteins/metabolism; Cadherins/metabolism; Cells, Cultured; Cohort Studies; Diabetes Mellitus/blood; Diabetes Mellitus/immunology; Diabetes Mellitus/metabolism; Diabetes Mellitus/pathology; Diabetic Retinopathy/blood; Diabetic Retinopathy/immunology; Diabetic Retinopathy/metabolism; Down-Regulation; Endothelial Progenitor Cells/immunology; Endothelial Progenitor Cells/metabolism; Endothelium, Vascular/immunology; Endothelium, Vascular/metabolism; Gene Expression Profiling; Glycoproteins/metabolism; Humans; Middle Aged; Peptides/metabolism; Period Circadian Proteins/antagonists & inhibitors; Period Circadian Proteins/blood; Period Circadian Proteins/genetics; RNA Interference; Toll-Like Receptors/genetics; Toll-Like Receptors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Cell Differentiation / MicroRNAs / Diabetic Retinopathy / Period Circadian Proteins / Endothelial Progenitor Cells Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies Language: En Journal: Diabetes Year: 2015 Document type: Article Affiliation country: India Country of publication: United States

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