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A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models.
Ye, Xiang S; Fan, Li; Van Horn, Robert D; Nakai, Ryuichiro; Ohta, Yoshihisa; Akinaga, Shiro; Murakata, Chikara; Yamashita, Yoshinori; Yin, Tinggui; Credille, Kelly M; Donoho, Gregory P; Merzoug, Farhana F; Li, Heng; Aggarwal, Amit; Blanchard, Kerry; Westin, Eric H.
Affiliation
  • Ye XS; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana. Ye_Xiang_S@lilly.com.
  • Fan L; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Van Horn RD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Nakai R; Drug Discovery Research Laboratories, Kyowa Hakko Kirin Co. Ltd., Shizuoka, Japan.
  • Ohta Y; Medicinal Chemistry Research Laboratories, Kyowa Hakko Kirin Co. Ltd., Shizuoka, Japan.
  • Akinaga S; Clinical Development Department 1, Development Division, Kyowa Hakko Kirin Co. Ltd., Shizuoka, Japan.
  • Murakata C; Medicinal Chemistry Research Laboratories, Kyowa Hakko Kirin Co. Ltd., Shizuoka, Japan.
  • Yamashita Y; Drug Discovery Research Laboratories, Kyowa Hakko Kirin Co. Ltd., Shizuoka, Japan.
  • Yin T; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Credille KM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Donoho GP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Merzoug FF; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Li H; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Aggarwal A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Blanchard K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
  • Westin EH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
Mol Cancer Ther ; 14(11): 2463-72, 2015 Nov.
Article in En | MEDLINE | ID: mdl-26304237
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thiadiazoles / Kinesins / Apoptosis / Mitosis / Neoplasms Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2015 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thiadiazoles / Kinesins / Apoptosis / Mitosis / Neoplasms Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2015 Document type: Article Country of publication: United States