Fluorescence and reflectance spectral imaging system for a murine mammary window chamber model.
Biomed Opt Express
; 6(8): 2887-94, 2015 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-26309753
ABSTRACT
A spectral imaging system was developed to study the development of breast cancer xenografts in a murine mammary window chamber model. The instrument is configured to work with either a laser to excite fluorescence or a broadband light source for diffuse reflectance imaging. Two applications were demonstrated. First, spectral imaging of fluorescence signals was demonstrated with a GFP-breast cancer tumor and fluorescein injection. Second, based on the principles of broadband reflectance spectroscopy, the instrument was used to monitor dynamic changes of tissue absorbance to yield tissue oxygenation maps at different time points during tumor progression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biomed Opt Express
Year:
2015
Document type:
Article
Affiliation country:
United States