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The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides.
Epp, Jeffrey B; Alexander, Anita L; Balko, Terry W; Buysse, Ann M; Brewster, William K; Bryan, Kristy; Daeuble, John F; Fields, Stephen C; Gast, Roger E; Green, Renard A; Irvine, Nicholas M; Lo, William C; Lowe, Christian T; Renga, James M; Richburg, John S; Ruiz, James M; Satchivi, Norbert M; Schmitzer, Paul R; Siddall, Thomas L; Webster, Jeffery D; Weimer, Monte R; Whiteker, Gregory T; Yerkes, Carla N.
Affiliation
  • Epp JB; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States. Electronic address: jbepp@dow.com.
  • Alexander AL; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Balko TW; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Buysse AM; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Brewster WK; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Bryan K; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Daeuble JF; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Fields SC; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Gast RE; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Green RA; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Irvine NM; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Lo WC; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Lowe CT; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Renga JM; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Richburg JS; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Ruiz JM; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Satchivi NM; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Schmitzer PR; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Siddall TL; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Webster JD; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Weimer MR; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Whiteker GT; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
  • Yerkes CN; Dow AgroSciences, 9330 Zionsville Rd, Indianapolis, IN 46268, United States.
Bioorg Med Chem ; 24(3): 362-71, 2016 Feb 01.
Article in En | MEDLINE | ID: mdl-26321602
Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex™ active (2005) and Rinskor™ active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Picloram / Oryza / Edible Grain / Drug Discovery / Herbicides / Indoleacetic Acids Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Picloram / Oryza / Edible Grain / Drug Discovery / Herbicides / Indoleacetic Acids Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Country of publication: United kingdom