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Are capillary DBS applicable for therapeutic drug monitoring of common antipsychotics? A proof of concept.
Patteet, Lisbeth; Maudens, Kristof E; Stove, Christophe P; Lambert, Willy E; Morrens, Manuel; Sabbe, Bernard; Neels, Hugo.
Affiliation
  • Patteet L; Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  • Maudens KE; Laboratory for TDM & Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerp, Belgium.
  • Stove CP; Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  • Lambert WE; Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
  • Morrens M; Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
  • Sabbe B; Collaborative Antwerp Psychiatric Research Institute (CAPRI), Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  • Neels H; Psychiatric Hospital Broeders Alexianen, Provinciesteenweg 408, B-2530 Boechout, Belgium.
Bioanalysis ; 7(16): 2119-30, 2015.
Article in En | MEDLINE | ID: mdl-26327190
ABSTRACT

AIM:

DBS sampling has been proposed as an alternative for venous blood collection in therapeutic drug monitoring (TDM) of antipsychotics. For implementation in routine practice, a comparison between capillary and venous blood concentrations is mandatory.

RESULTS:

A DBS method for quantification of antipsychotics was clinically validated. First, whole blood therapeutic ranges were calculated using the bloodserum ratio. Calculation of DBSblood ratios and Passing-Bablok regression analysis demonstrated that concentrations obtained by DBS analysis were highly comparable to those obtained by conventional whole blood analysis. Clinical interpretation of serum, whole blood and DBS concentrations were highly identical (sensitivity 91.6-97.6%).

CONCLUSION:

This is the first clinical study demonstrating the value of DBS sampling in TDM of antipsychotics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antipsychotic Agents / Drug Monitoring / Dried Blood Spot Testing Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Bioanalysis Year: 2015 Document type: Article Affiliation country: Belgium
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antipsychotic Agents / Drug Monitoring / Dried Blood Spot Testing Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Bioanalysis Year: 2015 Document type: Article Affiliation country: Belgium