The Impact of Gonadal Hormones on the Expression of Human Neurological Disorders.
Neuroendocrinology
; 103(5): 417-31, 2016.
Article
in En
| MEDLINE
| ID: mdl-26335277
ABSTRACT
The effects of gonadal steroids on neurological well-being and disease constitute a rich and rapidly expanding area of basic and clinical neuroscience. Gonadal hormones exert potent effects on monoaminergic, cholinergic and peptidergic pathways as well as neurosteroidogenesis which, in turn, impact normal brain organization and function. A spectrum of human neurological conditions are influenced by hormonal fluctuations associated with the menstrual cycle, pregnancy, the menopause and use of oral contraceptives. An appreciation of these relationships may facilitate the development of specific hormonal and anti-hormonal therapies for neurological disorders as disparate as catamenial epilepsy and acute intermittent porphyria.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gonadal Hormones
/
Nervous System Diseases
Limits:
Animals
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Neuroendocrinology
Year:
2016
Document type:
Article
Affiliation country:
Canada