Using GWAS to identify genetic predisposition in hepatic autoimmunity.

Webb, G J; Hirschfield, G M

Webb, G J; Hirschfield, G M.

Affiliation

Webb GJ; NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.
Hirschfield GM; NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK. Electronic address: g.hirschfield@bham.ac.uk.

J Autoimmun ; 66: 25-39, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26347073

Subject(s)

Autoimmunity/genetics; Cholangitis, Sclerosing/genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Hepatitis, Autoimmune/genetics; Liver Cirrhosis, Biliary/genetics; Adaptor Proteins, Signal Transducing; CD28 Antigens/genetics; CD28 Antigens/metabolism; Cholangitis, Sclerosing/immunology; Epistasis, Genetic; Fucosyltransferases/genetics; Fucosyltransferases/immunology; HLA Antigens/genetics; Haplotypes; Hepatitis, Autoimmune/immunology; Humans; Interleukin-12/genetics; Interleukin-12/metabolism; Interleukin-2/genetics; Interleukin-2/metabolism; Intracellular Signaling Peptides and Proteins; Liver/immunology; Liver Cirrhosis, Biliary/immunology; Polymorphism, Single Nucleotide; Proteins/genetics; Proteins/immunology; Risk Factors; STAT4 Transcription Factor/genetics; STAT4 Transcription Factor/metabolism; Signal Transduction/immunology; Galactoside 2-alpha-L-fucosyltransferase

Key words

Autoimmune hepatitis; Biliary autoimmunity; Epigenetics; Epistasis; Genetic risk; Heritability; Immune regulation; Primary biliary cirrhosis; Primary sclerosing cholangitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholangitis, Sclerosing / Autoimmunity / Hepatitis, Autoimmune / Genetic Predisposition to Disease / Genome-Wide Association Study / Liver Cirrhosis, Biliary Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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