Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.

Petruccelli, Emily; Lansdon, Patrick; Kitamoto, Toshihiro

Petruccelli, Emily; Lansdon, Patrick; Kitamoto, Toshihiro.

Affiliation

Petruccelli E; Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA, United States of America.
Lansdon P; Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA, United States of America.
Kitamoto T; Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA, United States of America; Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, IA, United States of America.

PLoS One ; 10(9): e0137758, 2015.

Article in En | MEDLINE | ID: mdl-26361221

Subject(s)

Epilepsy/etiology; Epilepsy/physiopathology; Homeostasis; Photoperiod; Sleep Deprivation; Animals; Animals, Genetically Modified; Circadian Rhythm; Disease Models, Animal; Disease Susceptibility; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Epilepsy, Generalized/etiology; Epilepsy, Generalized/physiopathology; Female; Homeostasis/genetics; Humans; Male; Mutation; Neurons/metabolism; Phenotype; Receptors, GABA-A/genetics; Receptors, GABA-A/metabolism; Seizures, Febrile/etiology; Seizures, Febrile/physiopathology; Sleep/drug effects; Sleep Deprivation/genetics; gamma-Aminobutyric Acid/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sleep Deprivation / Photoperiod / Epilepsy / Homeostasis Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: United States

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