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Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate.
Toriumi, Kazuya; Mamiya, Takayoshi; Song, Ziyu; Honjo, Tatsuki; Watanabe, Hiroyuki; Tanaka, Junko; Kondo, Mizuki; Mouri, Akihiro; Kim, Hyoung-Chun; Nitta, Atsumi; Fukushima, Takeshi; Nabeshima, Toshitaka.
Affiliation
  • Toriumi K; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Japan.
  • Mamiya T; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan.
  • Song Z; Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
  • Honjo T; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
  • Watanabe H; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
  • Tanaka J; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
  • Kondo M; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
  • Mouri A; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan.
  • Kim HC; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon, South Korea.
  • Nitta A; Department of Pharmaceutical Therapy & Neuropharmacology, Faculty of Pharmaceutical Science, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan.
  • Fukushima T; Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
  • Nabeshima T; Nabeshima Laboratory, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan. Electronic address: tnabeshi@ccalumni.meijo-u.ac.jp.
Eur Neuropsychopharmacol ; 25(11): 2108-17, 2015 Nov.
Article in En | MEDLINE | ID: mdl-26361739
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyltransferases / Brain / Aspartic Acid Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur Neuropsychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2015 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyltransferases / Brain / Aspartic Acid Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur Neuropsychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2015 Document type: Article Affiliation country: Japan