Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site.

Heydenreuter, Wolfgang; Kunold, Elena; Sieber, Stephan A

Heydenreuter, Wolfgang; Kunold, Elena; Sieber, Stephan A.

Affiliation

Heydenreuter W; Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Garching, Germany. stephan.sieber@tum.de.
Kunold E; Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Garching, Germany. stephan.sieber@tum.de.
Sieber SA; Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Garching, Germany. stephan.sieber@tum.de.

Chem Commun (Camb) ; 51(87): 15784-7, 2015 Nov 11.

Article in En | MEDLINE | ID: mdl-26365706

Subject(s)

Aldehyde Dehydrogenase/antagonists & inhibitors; Alkynes/pharmacology; Antineoplastic Agents/pharmacology; Diynes/pharmacology; Enzyme Inhibitors/pharmacology; Fatty Alcohols/pharmacology; Aldehyde Dehydrogenase/chemistry; Aldehyde Dehydrogenase, Mitochondrial; Alkynes/chemical synthesis; Antineoplastic Agents/chemical synthesis; Catalytic Domain; Click Chemistry; Cysteine/chemistry; Diynes/chemical synthesis; Enzyme Inhibitors/chemical synthesis; Fatty Alcohols/chemical synthesis; Hep G2 Cells; Humans; Kinetics; Recombinant Proteins/chemistry

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aldehyde Dehydrogenase / Alkynes / Enzyme Inhibitors / Diynes / Fatty Alcohols / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Germany Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google