New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches.
EuPA Open Proteom
; 3: 262-272, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-26366373
ABSTRACT
FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flp and flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
EuPA Open Proteom
Year:
2014
Document type:
Article
Affiliation country:
United kingdom