Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases.

Kolrep, Franziska; Hessel, Stefanie; These, Anja; Ehlers, Anke; Rein, Kathleen; Lampen, Alfonso

Kolrep, Franziska; Hessel, Stefanie; These, Anja; Ehlers, Anke; Rein, Kathleen; Lampen, Alfonso.

Affiliation

Kolrep F; Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Hessel S; Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany. stefanie.hessel@bfr.bund.de.
These A; Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Ehlers A; Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.
Rein K; Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Lampen A; Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany.

Arch Toxicol ; 90(8): 2025-36, 2016 Aug.

Article in En | MEDLINE | ID: mdl-26374342

Subject(s)

Cytochrome P-450 CYP1A2/metabolism; Cytochrome P-450 CYP3A/metabolism; Liver/drug effects; Marine Toxins/toxicity; Okadaic Acid/toxicity; Animals; Cell Culture Techniques; Cell Survival/drug effects; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2/genetics; Cytochrome P-450 CYP3A/genetics; Hep G2 Cells; Humans; Liver/enzymology; Rats; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Species Specificity; Tandem Mass Spectrometry

Key words

Cytochrome P450 monooxygenases; HPLC-MS/MS; Okadaic acid; Phase I metabolism; Species differences

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Okadaic Acid / Cytochrome P-450 CYP1A2 / Cytochrome P-450 CYP3A / Liver / Marine Toxins Limits: Animals / Humans Language: En Journal: Arch Toxicol Year: 2016 Document type: Article Affiliation country: Germany Country of publication: Germany

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