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(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.
Dzien, Piotr; Tee, Sui-Seng; Kettunen, Mikko I; Lyons, Scott K; Larkin, Timothy J; Timm, Kerstin N; Hu, De-En; Wright, Alan; Rodrigues, Tiago B; Serrao, Eva M; Marco-Rius, Irene; Mannion, Elizabeth; D'Santos, Paula; Kennedy, Brett W C; Brindle, Kevin M.
Affiliation
  • Dzien P; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Tee SS; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
  • Kettunen MI; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Lyons SK; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
  • Larkin TJ; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Timm KN; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
  • Hu DE; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Wright A; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
  • Rodrigues TB; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Serrao EM; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Marco-Rius I; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Mannion E; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
  • D'Santos P; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
  • Kennedy BW; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Brindle KM; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
Magn Reson Med ; 76(2): 391-401, 2016 08.
Article in En | MEDLINE | ID: mdl-26388418

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Pyruvate Decarboxylase / Magnetic Resonance Imaging / Zymomonas / Pyruvic Acid / Molecular Imaging / Carbon-13 Magnetic Resonance Spectroscopy Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Magn Reson Med Journal subject: DIAGNOSTICO POR IMAGEM Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Proteins / Pyruvate Decarboxylase / Magnetic Resonance Imaging / Zymomonas / Pyruvic Acid / Molecular Imaging / Carbon-13 Magnetic Resonance Spectroscopy Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Magn Reson Med Journal subject: DIAGNOSTICO POR IMAGEM Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United States