Your browser doesn't support javascript.
loading
Vaxvec: The first web-based recombinant vaccine vector database and its data analysis.
Deng, Shunzhou; Martin, Carly; Patil, Rasika; Zhu, Felix; Zhao, Bin; Xiang, Zuoshuang; He, Yongqun.
Affiliation
  • Deng S; Department of Veterinary Medicine, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Martin C; College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
  • Patil R; College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
  • Zhu F; College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
  • Zhao B; Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA; School of Information, University of Michigan, Ann Arbor, MI 48109, USA.
  • Xiang Z; Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • He Y; Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI 48109
Vaccine ; 33(48): 6938-46, 2015 Nov 27.
Article in En | MEDLINE | ID: mdl-26403370
A recombinant vector vaccine uses an attenuated virus, bacterium, or parasite as the carrier to express a heterologous antigen(s). Many recombinant vaccine vectors and related vaccines have been developed and extensively investigated. To compare and better understand recombinant vectors and vaccines, we have generated Vaxvec (http://www.violinet.org/vaxvec), the first web-based database that stores various recombinant vaccine vectors and those experimentally verified vaccines that use these vectors. Vaxvec has now included 59 vaccine vectors that have been used in 196 recombinant vector vaccines against 66 pathogens and cancers. These vectors are classified to 41 viral vectors, 15 bacterial vectors, 1 parasitic vector, and 1 fungal vector. The most commonly used viral vaccine vectors are double-stranded DNA viruses, including herpesviruses, adenoviruses, and poxviruses. For example, Vaxvec includes 63 poxvirus-based recombinant vaccines for over 20 pathogens and cancers. Vaxvec collects 30 recombinant vector influenza vaccines that use 17 recombinant vectors and were experimentally tested in 7 animal models. In addition, over 60 protective antigens used in recombinant vector vaccines are annotated and analyzed. User-friendly web-interfaces are available for querying various data in Vaxvec. To support data exchange, the information of vaccine vectors, vaccines, and related information is stored in the Vaccine Ontology (VO). Vaxvec is a timely and vital source of vaccine vector database and facilitates efficient vaccine vector research and development.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Vaccines, Synthetic / Databases, Factual / Databases, Genetic / Genetic Vectors Limits: Animals / Humans Language: En Journal: Vaccine Year: 2015 Document type: Article Affiliation country: United States Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Vaccines, Synthetic / Databases, Factual / Databases, Genetic / Genetic Vectors Limits: Animals / Humans Language: En Journal: Vaccine Year: 2015 Document type: Article Affiliation country: United States Country of publication: Netherlands