Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

Masini, T; Lacy, B; Monjas, L; Hawksley, D; de Voogd, A R; Illarionov, B; Iqbal, A; Leeper, F J; Fischer, M; Kontoyianni, M; Hirsch, A K H

Masini, T; Lacy, B; Monjas, L; Hawksley, D; de Voogd, A R; Illarionov, B; Iqbal, A; Leeper, F J; Fischer, M; Kontoyianni, M; Hirsch, A K H.

Affiliation

Masini T; Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands. a.k.h.hirsch@rug.nl.

Org Biomol Chem ; 13(46): 11263-77, 2015 Dec 14.

Article in En | MEDLINE | ID: mdl-26411373

Subject(s)

Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Mycobacterium tuberculosis/enzymology; Thiamine/analogs & derivatives; Thiamine/pharmacology; Transferases/antagonists & inhibitors; Transferases/chemistry; Deinococcus/chemistry; Deinococcus/enzymology; Drug Design; Humans; Molecular Docking Simulation; Mycobacterium tuberculosis/chemistry; Mycobacterium tuberculosis/drug effects; Protein Conformation; Structural Homology, Protein; Transferases/metabolism; Tuberculosis/drug therapy; Tuberculosis/microbiology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiamine / Transferases / Enzyme Inhibitors / Mycobacterium tuberculosis Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google