Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins.

Liu, Jun; Yadav, Sandeep; Andya, James; Demeule, Barthélemy; Shire, Steven J

Liu, Jun; Yadav, Sandeep; Andya, James; Demeule, Barthélemy; Shire, Steven J.

Affiliation

Liu J; Late Stage Pharamaceutical and Processing Development, Genentech.
Yadav S; Late Stage Pharamaceutical and Processing Development, Genentech.
Andya J; Late Stage Pharamaceutical and Processing Development, Genentech.
Demeule B; Late Stage Pharamaceutical and Processing Development, Genentech.
Shire SJ; Late Stage Pharamaceutical and Processing Development, Genentech. Electronic address: shire.steve@gene.com.

Methods Enzymol ; 562: 441-76, 2015.

Article in En | MEDLINE | ID: mdl-26412663

Subject(s)

Antibodies, Monoclonal/isolation & purification; Algorithms; Antibodies, Monoclonal/chemistry; Binding, Competitive; Drug Discovery; Humans; Models, Molecular; Molecular Weight; Protein Binding; Recombinant Proteins/chemistry; Recombinant Proteins/isolation & purification; Ultracentrifugation

Key words

Analytical ultracentrifugation; Competitive binding; Monoclonal antibody complexes; Proteinprotein interactions; Self-association; Viscosity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Methods Enzymol Year: 2015 Document type: Article

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