Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.
Nano Lett
; 15(11): 7488-96, 2015 Nov 11.
Article
in En
| MEDLINE
| ID: mdl-26418302
ABSTRACT
More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Metal Nanoparticles
/
Gold
/
Neoplasms
/
Neovascularization, Pathologic
Limits:
Humans
Language:
En
Journal:
Nano Lett
Year:
2015
Document type:
Article
Affiliation country:
United States