The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.
FEBS Lett
; 589(22): 3362-9, 2015 Nov 14.
Article
in En
| MEDLINE
| ID: mdl-26424657
ABSTRACT
The term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmunity
/
Interleukin-10
/
B-Lymphocytes, Regulatory
/
Infections
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS Lett
Year:
2015
Document type:
Article
Affiliation country:
Argentina