Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner.
Psychoneuroendocrinology
; 63: 198-207, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26460782
ABSTRACT
The beneficial effects of calorie restriction (CR) have been described at both organismal and cellular levels in multiple organs. However, our understanding of the causal mediators of such hormesis is poorly understood, particularly in the context of higher brain function. Here, we show that the receptor for the orexigenic hormone acyl-ghrelin, the growth hormone secretagogue receptor (Ghsr), is enriched in the neurogenic niche of the hippocampal dentate gyrus (DG). Acute elevation of acyl-ghrelin levels by injection or by overnight CR, increased DG levels of the neurogenic transcription factor, Egr-1. Two weeks of CR increased the subsequent number of mature newborn neurons in the DG of adult wild-type but not Ghsr(-/-) mice. CR wild-type mice also showed improved remote contextual fear memory. Our findings suggest that Ghsr mediates the beneficial effects of CR on enhancing adult hippocampal neurogenesis and memory.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mental Recall
/
Caloric Restriction
/
Adult Stem Cells
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Receptors, Ghrelin
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Neurogenesis
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Fear
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Neural Stem Cells
/
Hippocampus
Limits:
Animals
Language:
En
Journal:
Psychoneuroendocrinology
Year:
2016
Document type:
Article
Affiliation country:
United kingdom