iNOS null MRL+/+ mice show attenuation of trichloroethene-mediated autoimmunity: contribution of reactive nitrogen species and lipid-derived reactive aldehydes.

Wang, Gangduo; Wakamiya, Maki; Wang, Jianling; Ansari, G A S; Firoze Khan, M

Wang, Gangduo; Wakamiya, Maki; Wang, Jianling; Ansari, G A S; Firoze Khan, M.

Affiliation

Wang G; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.
Wakamiya M; Transgenic Mouse Core Facility, Institute for Translational Sciences and Animal Resource Center.
Wang J; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.
Ansari GA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555.
Firoze Khan M; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555. Electronic address: mfkhan@utmb.edu.

Free Radic Biol Med ; 89: 770-6, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26472195

Subject(s)

Aldehydes/metabolism; Autoimmunity/physiology; Nitric Oxide Synthase Type II/metabolism; Reactive Nitrogen Species/metabolism; Trichloroethylene/toxicity; Aldehydes/immunology; Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Lipid Metabolism; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Nitric Oxide Synthase Type II/immunology; Reactive Nitrogen Species/immunology; Real-Time Polymerase Chain Reaction

Key words

Autoantibody; Autoimmunity; Free radical; INOS; Trichloroethene

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trichloroethylene / Autoimmunity / Reactive Nitrogen Species / Aldehydes / Nitric Oxide Synthase Type II Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2015 Document type: Article Country of publication: United States

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