Pentafluorophenyl Ester-based Polymersomes as Nanosized Drug-Delivery Vehicles.
Macromol Rapid Commun
; 37(1): 60-66, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26480295
ABSTRACT
In this work, activated ester chemistry is employed to synthesize biocompatible and readily functionalizable polymersomes. Via aminolysis of pentafluorophenyl methacrylate-based precursor polymers, an N-(2-hydroxypropyl) methacrylamide (HPMA)-analog hydrophilic block is obtained. The precursor polymers can be versatile functionalized by simple addition of suitable primary amines during aminolysis as demonstrated using a fluorescent dye. Vesicle formation is proven by cryoTEM and light scattering. High encapsulation efficiencies for hydrophilic cargo like siRNA are achieved using dual centrifugation and safe encapsulation is demonstrated by gel electrophoresis. In vitro studies reveal low cytotoxicity and no protein adsorption-induced aggregation in human blood serum occurs, making the vesicles interesting candidates as nanosized drug carriers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Macromol Rapid Commun
Year:
2016
Document type:
Article
Affiliation country:
Germany