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A Diffusion Tensor Imaging Study Using a Voxel-Based Analysis, Region-of-Interest Method to Analyze White Matter Abnormalities in First-Episode, Treatment-Naïve Major Depressive Disorder.
Srivastava, Shruti; Bhatia, Manjeet S; Bhargava, S K; Kumari, Rima; Chandra, Sushil.
Affiliation
  • Srivastava S; From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept.,
  • Bhatia MS; From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept.,
  • Bhargava SK; From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept.,
  • Kumari R; From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept.,
  • Chandra S; From the Depts. of Psychiatry (SS, MSB) and Radiology (SKB), University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, India; the Dept. of Neuroradiology, Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi, India (RK); and the BioMedical Dept.,
J Neuropsychiatry Clin Neurosci ; 28(2): 131-7, 2016.
Article in En | MEDLINE | ID: mdl-26548656
This study used fractional anisotropy (FA), a measure of diffusion tensor imaging, to analyze white matter abnormalities in 15 first-episode treatment-naïve patients with major depressive disorder (MDD) and 15 controls matched for age. An automated voxel-based analysis and a region-of-interest (ROI) method with 3T magnetic resonance imaging were used. Compared with controls, FA values were lower in the left superior longitudinal fasciculus, the left prefrontal cortex, and the left parietal region in patients with MDD. In addition, the ROI method revealed significantly lower FA values in the right hippocampus. Voxel-based analysis, a faster technique, complements the ROI method, which highlights FA values as potential biomarkers in early MDD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Depressive Disorder, Major / Diffusion Tensor Imaging / White Matter / Nerve Net Type of study: Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male Language: En Journal: J Neuropsychiatry Clin Neurosci Journal subject: NEUROLOGIA / PSIQUIATRIA Year: 2016 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Depressive Disorder, Major / Diffusion Tensor Imaging / White Matter / Nerve Net Type of study: Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male Language: En Journal: J Neuropsychiatry Clin Neurosci Journal subject: NEUROLOGIA / PSIQUIATRIA Year: 2016 Document type: Article Country of publication: United States