Increased homocysteine levels exist in women with preeclampsia from early pregnancy.
J Matern Fetal Neonatal Med
; 29(16): 2719-25, 2016.
Article
in En
| MEDLINE
| ID: mdl-26552939
ABSTRACT
OBJECTIVE:
The present prospective study examines the levels of maternal plasma folate, vitamin B12 and homocysteine in normotensive control (NC) women and women with preeclampsia (PE) from early pregnancy till delivery.METHODS:
The present study includes 126 NC and 62 PE women. Maternal blood was collected at 3 time points during pregnancy (T1 = 16th-20th weeks, T2 = 26th-30th weeks and T3 = at delivery). Levels of folate, vitamin B12 and homocysteine were estimated by the chemiluminescent microparticle immunoassay technology.RESULTS:
Maternal plasma folate levels were similar between NC and PE women at all the time points across gestation. Maternal plasma vitamin B12 levels were significantly higher in PE (p < 0.05) as compared with NC at T2. Maternal plasma homocysteine levels were higher in PE as compared with NC at all the time points, i.e. T1, T2 (p < 0.05 for both) and T3 (p < 0.01).CONCLUSION:
Our results indicate that higher homocysteine levels exist in women with PE from early pregnancy and continue till delivery.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Gestational Age
/
Homocysteine
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
J Matern Fetal Neonatal Med
Journal subject:
OBSTETRICIA
/
PERINATOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
India