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NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
Kondylis, Vangelis; Polykratis, Apostolos; Ehlken, Hanno; Ochoa-Callejero, Laura; Straub, Beate Katharina; Krishna-Subramanian, Santosh; Van, Trieu-My; Curth, Harald-Morten; Heise, Nicole; Weih, Falk; Klein, Ulf; Schirmacher, Peter; Kelliher, Michelle; Pasparakis, Manolis.
Affiliation
  • Kondylis V; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Polykratis A; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Ehlken H; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Ochoa-Callejero L; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Straub BK; Institute of Pathology, University Hospital Heidelberg, INF 224, 69120 Heidelberg, Germany.
  • Krishna-Subramanian S; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Van TM; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Curth HM; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.
  • Heise N; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.
  • Weih F; Leibniz-Institute for Age Research-Fritz-Lipmann-Institute, 07745 Jena, Germany.
  • Klein U; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA.
  • Schirmacher P; Institute of Pathology, University Hospital Heidelberg, INF 224, 69120 Heidelberg, Germany.
  • Kelliher M; Department of Molecular, Cellular and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Pasparakis M; Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany. El
Cancer Cell ; 28(5): 582-598, 2015 11 09.
Article in En | MEDLINE | ID: mdl-26555174
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Hepatocytes / Intracellular Signaling Peptides and Proteins / Receptor-Interacting Protein Serine-Threonine Kinases / Fatty Liver / Liver Neoplasms Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2015 Document type: Article Affiliation country: Germany Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Hepatocytes / Intracellular Signaling Peptides and Proteins / Receptor-Interacting Protein Serine-Threonine Kinases / Fatty Liver / Liver Neoplasms Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2015 Document type: Article Affiliation country: Germany Country of publication: United States