Advantage of tacrolimus/mycophenolate mofetil regimen for cytotoxic T cell-mediated defence and its inhibition by additive steroid administration in high-risk liver transplant recipients.

Uemoto, S; Ozawa, K; Kaido, T; Mori, A; Fujimoto, Y

Uemoto, S; Ozawa, K; Kaido, T; Mori, A; Fujimoto, Y.

Affiliation

Uemoto S; Department of Surgery, Graduate School of Medicine, Kyoto University, Japan.
Ozawa K; Hepatic Disease Research Institute, Kyoto, Japan.
Kaido T; Department of Surgery, Graduate School of Medicine, Kyoto University, Japan.
Mori A; Department of Surgery, Graduate School of Medicine, Kyoto University, Japan.
Fujimoto Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Japan.

Clin Exp Immunol ; 184(1): 126-36, 2016 Apr.

Article in En | MEDLINE | ID: mdl-26560892

Subject(s)

Graft Rejection/prevention & control; Immunosuppressive Agents/therapeutic use; Liver Transplantation; Methylprednisolone/adverse effects; Mycophenolic Acid/analogs & derivatives; T-Lymphocytes, Cytotoxic/drug effects; Tacrolimus/therapeutic use; Aged; Female; Gene Expression; Graft Rejection/immunology; Graft Rejection/mortality; Graft Rejection/pathology; Graft Survival; Humans; Hyperparathyroidism/immunology; Hyperparathyroidism/mortality; Hyperparathyroidism/pathology; Hyperparathyroidism/surgery; Immunologic Memory; Interferon-gamma/genetics; Interferon-gamma/immunology; Living Donors; Male; Middle Aged; Mycophenolic Acid/therapeutic use; Perforin/genetics; Perforin/immunology; Receptors, Interleukin-12/genetics; Receptors, Interleukin-12/immunology; Retrospective Studies; Survival Analysis; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Cytotoxic/pathology; Unrelated Donors

Key words

IL-12Rß1+ cells; central memory T cells; highest pre-existing effector T cells; immunosuppressive regimen; living donor liver transplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylprednisolone / T-Lymphocytes, Cytotoxic / Liver Transplantation / Tacrolimus / Graft Rejection / Immunosuppressive Agents / Mycophenolic Acid Type of study: Etiology_studies / Observational_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Exp Immunol Year: 2016 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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